“The exciting results we report today suggest that the Neuregulin 1 pathway provides promising points of intervention for the development of effective new treatments for schizophrenia,” said Dr. Later-stage drug development work in schizophrenia will be conducted under deCODE’s therapeutics alliance with Roche. deCODE has already performed a high-throughput screen against a promising target within the neuregulin pathway and is continuing its drug discovery work at its Chicago-based pharmaceuticals group. The deCODE team analyzed mice in which certain segments of the Neuregulin 1 or of one of its key receptors, ERB4, were knocked out, and found that the knockout mice exhibited behaviors and disruptions in normal neurotransmission similar to those seen in schizophrenics. Although no previous research has established a link between Neuregulin 1 and schizophrenia, it is critical to neuronal development and to the proper transmission of messages within the central nervous system (CNS). ![]() The findings reported today are further supported by at least five previous studies that offered suggestive linkage between schizophrenia and a region on the short arm of chromosome 8 containing the Neuregulin 1 gene.ĭeCODE’s functional studies in mice offer compelling additional evidence for the involvement of the Neuregulin 1 pathway in some of the major biological dysfunctions in schizophrenia. Preliminary data from association studies in Western European and Asian cohorts suggest that this haplotype is also significantly linked to the disease in broader populations. Company scientists used this data to home in on a particular haplotype – a small segment of DNA that is inherited as a unit – within Neuregulin 1 that appears to confer more than twice the average risk for developing schizophrenia. deCODE’s research brought together genome-wide and detailed genotypic data from more than 800 volunteer patients and unaffected relatives from across Iceland. These include a genealogical database covering the entire Icelandic population unrivalled genotyping capacity and know-how and the company’s high-density genetic map of the human genome. The causes of schizophrenia are unknown, but the disease tends to run in certain families and is thus known to have a significant genetic component.ĭeCODE scientists succeeded in establishing the link between schizophrenia and the Neuregulin 1 gene, located on the short arm of chromosome 8, by leveraging the company’s unique resources for pinpointing key genes involved in common diseases. ![]() Patients frequently suffer from delusions, hallucinations, and blunted emotions, and current treatments are effective only in alleviating some of these symptoms. The paper, entitled “Neuregulin 1 and susceptibility to schizophrenia,” is published in the online edition of the American Journal of Human Genetics, accessible at Schizophrenia is a chronic and progressive mental illness affecting between 0.5 and 1.0 percent of the adult population worldwide. The Neuregulin pathway has yielded druggable targets which deCODE is employing in its collaboration with Roche to discover new and more effective treatments for schizophrenia. Reykjavik, ICELAND, JdeCODE genetics (Nasdaq/Nasdaq Europe:DCGN) today announced the publication of a paper by a deCODE-led team of scientists describing the company’s pioneering work on the genetics of schizophrenia.The paper presents data from deCODE’s pathbreaking population genetics research linking Neuregulin 1 to schizophrenia, as well as the results of subsequent functional studies underscoring the role of this gene in the pathology of the disease. ![]() Research yields promising drug targets impacting underlying biology of the disease Findings form the basis of deCODE’s most advanced drug discovery program
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In the quest for the perfect barbeque sauce, Ashley Food Company was officially born. About five years in, I was so busy filling Mad Dog orders for my friends that my wife gave me a little friendly encouragement to move operations out of our tiny kitchen and into commercial production. I didn’t have a big factory, so instead, I founded what turned into Ashley Food Company out of my own Brighton, Massachusetts kitchen. That’s something that’s stuck with me in the years since.įlashforward about a decade and I started experimenting with my own version of the perfect barbeque sauce at home. ![]() It was there I learned how to multi-task and, perhaps more importantly, to always use high-quality ingredients. There’s only about 2,000 people in the entire town today, but I managed more than 90 people as General Manager of Alice’s. The town is hardly what you’d call large. That’s when I started working as General Manager of Alice’s Restaurant in Stockbridge, Massachusetts. I credit some of the success of Ashley Food Company to a job I first took around the mid 1970s. Sure, Mad Dog 357 may be well known among hot sauce aficionados today, but it took a lot of hard work to get where we are. But the truth is, I learned some of the keys to success well before I first started experimenting with new hot sauce flavors. ![]() Hot sauce is something I’ve been perfecting for nearly 40 years. Making a hot sauce I knew I’d enjoy, and my friends would enjoy too, is something that grew into a real passion that’s only increased over the years. One of our most popular flavors, Mad Dog Inferno Hot Sauce, was the very first hot sauce to ever be named the World’s Hottest Sauce and Mad Cat Hot Sauce took first place in the category Habanero Hot Sauce during Fiery Foods & Barbecue Magazine’s Scovie Awards.įor me, starting Ashley Food Company and making Mad Dog 357 hot sauce wasn’t just another business venture. In the early 2000s, Southern Living called Mad Dog the “Best Bottled BBQ Sauce” they’d ever tried. Cook’s Illustrated once deemed Mad Dog BBQ Sauce the “Original Best in USA”. In recent years, some of our favorite flavors and combinations have picked up countless awards. Whether you’re in search of hot sauce or pepper extracts, pepper powder or pepper purees, Mad Dog 357 specializes in some of the hottest hot sauces and pepper products around. In addition, we now sell pepper pods, and for those who really like to take it to the extreme no matter where they go, there’s our Mad Dog 357 Pain on a Chain. Our Mad Dog 357 Plutonium No 9 itself is nine million Scoville and one of the purest and hottest pepper extracts on the planet! Just one bottle uses 1,000 ounces of raw peppers. Mad Dog 357 Gold Edition Hot Sauce has a whopping one million SHU and is packed with nine million Scoville Plutonium Extract. We combined Carolina Reapers, Scorpion and Ghost Peppers, then added plutonium. We really took it to the extreme with Mad Dog 357 Gold Edition Hot Sauce. We’ve also added some other combinations over the years too, like Mad Dog 357 Silver Edition Hot Sauce, Mad Dog 357 Ghost Hot Sauce, and Mad Dog 357 Reaper Sriracha Hot Sauce. To put it in perspective, that’s extremely hot! To reach such a fiery level on the heat scale, we combined cayenne peppers, habanero peppers, and pepper extract into one extremely hot sauce. The original Mad Dog 357 hot sauce contains 357,000 SHU. Not only are Mad Dog 357 hot sauces and pepper products extremely popular, but they’re also packed with some of the world’s hottest peppers. These days, Ashley Food Company makes some of the hottest products on the planet. For me, that meant using natural ingredients, but also crafting something that tasted great and gave people something unexpected to look forward to. Sure, there are all kinds of commercially produced brands out there, but when I first started making Mad Dog 357 it wasn’t because I wanted to replicate something already on the market. When you choose a bottle of hot sauce, you’re looking for something that not only tastes great, but also adds a bit of a kick. From my own kitchen to the world: How I grew Mad Dog 357 into one of the hottest brands around Fix PDF search result highlighting disappearing too quickly.Fix blocking UI while performing long PDF searches.Fix repeated PDF searches with the same search string but different search flags.Fix (potential) non-sequential ordering of PDF search results.Fix focusing of the console when typesetting from the preview.Fix the PDF preview of files that are in the process of being changed (e.g., during typesetting).Fix crash when killing a typesetting process by closing the source window.Fix crash when closing a source opened after the preview.Update the libraries for the pre-built binaries. ![]()
![]() Visit your local BMW website or see your authorised BMW M Retailer for accurate details on the offers in your country. In no way do they constitute a binding offer by the BMW M GmbH. Īll vehicles, equipment, combination possibilities and varieties shown here are examples and can differ in your country. įor further information about the official fuel consumption and the specific CO2 emission of new passenger cars can be taken out of the „handbook of fuel consumption, the CO2 emission and power consumption of new passenger cars“, which is available at all selling points and at. For more information on the WLTP and NEDC measurement procedures, see. For newly type-tested vehicles since, the official data no longer exist according to NEDC, but only according to WLTP. A car scratch remover that also restores paint. Shine Armor Revive Scratch Repair Swirl Remover. WLTP values are used for assessing taxes and other vehicle-related charges that are (also) based on CO2 emissions, as well as for the purposes of vehicle-specific subsidies, if applicable. Where applicable, the NEDC values listed were calculated based on the new WLTP measurement procedure and then converted back to the NEDC measurement procedure for comparability reasons. A popular product that comes with the liquid and a scrubber. In case of a range, figures in the NEDC take into account differences in the selected wheel and tire size figures in the WLTP take into account any optional equipment. ![]() Official data on power consumption and electric range were determined in accordance with the mandatory measurement procedure and comply with Regulation (EU) 715/2007 valid at the time of type approval. The models illustrated include optional equipment.ĭue to regular software updates, screen designs in the communication may differ from the actual screen design in your car. An unnecessarily large wallet can result in unused space, potentially have more points of entry for water to get in, or can weigh you down in wet conditions. Capacity: Pick a wallet that can fit your most essential credit cards and some spare cash if needed, and avoid getting a bigger wallet than you need.If you choose one with the materials and hardware mentioned above, chances are it’ll have long-lasting durability. Durability: Generally, waterproof and weather-resistant wallets will be heavy-duty enough for everyday carry.For a more weather-resistant front pocket wallet, look for features like watertight zip closures, sealed seams, and clasps to keep water out. Functionality: EDC wallets usually prioritize easy access and slimness over everything.Instead, look for technical synthetic fabrics and anti-corrosive metals to protect from moisture. Materials: When it comes to the best waterproof wallets, you want to avoid canvas wallets or leather wallets that soak up water and get damaged.When selecting a wallet for everyday carry that’ll hold up in wet conditions, consider the following: Some are the same for any wallet, while others are more specific to resisting water. There are several factors to consider when choosing a waterproof wallet. How to Choose the Best Waterproof Wallet for EDC Key Features: Double-stitched nylon piping ![]() Key Features: Welded seams, floats in water The Most Versatile Waterproof Wallet: Alpaka Zip Pouch The Most Protective Wateproof Wallet: Pelican G5 RF Field / The Most Waterproof Wallet: NiteIze Runoff Pocket / The Best Budget Waterproof Wallet: Count圜omm Matrix The Best Overall Waterproof Wallet: Skog Å Kust Plånbok This guide will highlight waterproof and highly water-resistant wallets that won’t leave you peeling apart soggy bills. One way to ensure your valuables stay nice and dry is to pick up a quality waterproof wallet. For example, you don’t want your wallet bleeding dye into your pants or peeling apart after getting caught in a rainstorm or spilling your drink at the bar. While materials are essential for any item in your everyday carry, you should also keep carry conditions in mind. But it won't be so kind to your favorite EDC wallet, even if it's made with the best leather. To learn more about the five features of a perfect rain jacket, read our article.Water can be your best friend on a hot day. It is also important to check that the zippers and seams on your jacket are sealed so that water doesn’t come through the small gaps. As a benchmark, most Gore-Tex jackets have a 28,000 mm Schmerber rating. The higher the rating, the more waterproof the material. ![]() To find out just how waterproof a garment is, you’ll need to check the label for a metric called the Schmerber (10,000 Schmerber = 10,000 mm of water, which means the fabric would resist the pressure of a 10 m column of water). The well-known Gore-Tex membrane, the Omni-Tech® technology or the OutDry™ Extreme technology are all prime examples of microporous waterproof-breathable membranes which provide just the right balance between waterproofing and breathability. That’s why outdoor jackets are often made using a waterproof-breathable membrane, which protects against the weather and lets sweat escape out. The membrane in waterproof jackets is so tightly woven that nothing, not even rain or debris such as mud, dust or sand, gets through.īut waterproofing materials are usually not very breathable (think of a plastic bag or a poncho). Waterproofing technology provides the highest level of protection against the rain. To ensure your jacket lasts longer and improve its water resistance, don’t hesitate to spray the outer layer with a water-resistant treatment on a regular basis.įor everything you need to know about the criteria to consider when selecting rain gear, read our article.Įverything you need to know about waterproof jackets These types of jackets are usually lightweight, breathable and compact, and sometimes made using stretchy materials, which provide more freedom of movement and are less noisy than some other waterproof jacket models. There are also new water-resistant technologies on the market, such as Omni-Shield™, which can withstand light showers, is stain-proof and dries quickly. ![]() In general, water-resistant outdoor jackets are made using synthetic materials such as polyester (which is also durable and crease-proof) or nylon (water-resistant but not very breathable). ![]() However, they will not keep you dry in heavy downpours. Water-resistant jackets can therefore withstand light rain showers. It is made using fabric that is so tightly woven that water struggles to get through and beads up on the surface instead. Everything you need to know about water-resistant jacketsĪ water-resistant membrane is the first level of protection against rain. ![]() Jeg har brugt det i et par måneder og kan slet ikke. Den basale uninstaller på Windows kan slet ikke sammenlignes hermed, det renser grundigt alle rester af programmer, så der ikke forekommer nogen forsinkelser på computeren. IObit Uninstaller not only does a fantastic job when performing a normal. ![]() I had recommended this program to some of my friends in the past and would recommend it again today. Describe in depth about the main functions of IObit flagship products including Advanced SystemCare, Driver Booster, IObit Malware Fighter, etc. IObit Uninstaller er det bedste program til at fjerne programmer på din computer, det er hurtigt og super effektivt. IObit Uninstaller is a perfect uninstall tool, which provides an easy and secure way to thoroughly remove unwanted programs, malicious/ad browser extensions as well as Windows Apps, giving you a clean PC and a secure & smooth online surfing experience. I have been using this program for a several years and always it helps to keep my computer clean and fast. Unlike the basic windows uninstaller that program will remove all leftovers of the program, which later may slow down performance of your PC. "IObit Uninstaller is probably one of the best software to remove unnecessary program from your computer. IObit Uninstaller 9 uses new technologies to make program uninstallation more thorough and improve software health on Windows. Competing free tools perform similar functions, but IObit Uninstaller bests those rivals with its community-based suggestions and ability to remove annoying Web browser toolbars and plug-ins." Sergey Erlich "IObit Uninstaller is probably one of the best software to remove unnecessary program from your computer." This free utility makes it a breeze to delete apps, including stray files that are often left behind when you use Windows to delete software from your hard drive or SSD. "If you need a program that lets you cleanly and completely uninstall applications, fire up IObit Uninstaller. IObit Uninstaller 13 has also improved the Software Health feature. It removes leftovers and unnecessary programs, including Windows Apps, Universal Windows Platform (UWP) apps, and malicious/ad plugins. PC Magazine "IObit Uninstaller is easily the best Windows uninstaller utility I've tested." IObit Uninstaller is the one you can trust, no matter programs no longer being used, cant being uninstalled through standard uninstallation or bundled with. About IObit Uninstaller 13 : This uninstaller is for Windows users who want a clean PC and a safe online browsing experience. You can also read our full PDF Expert review for more. You can try PDF Expert for free to test it for yourself. PDF Expert also supports OCR scanning and signing of documents plus text to speech. PDF Expert can edit PDFs, images and links as well as convert PDF documents to Word, Excel and Powerpoint. PDF Expert has a very clean interface that looks like it was made for macOS and iOS. The lack of update support means that eventually it will stop working with new releases of macOS but you should get many years of use out of it. The one time purchase of PDF Expert offers all the same features as the subscription version, minus mobile access and updates. PDF Expert also offers a lifetime license for $139.99 so you can use it for an unlimited time as long as it remains compatible with the latest versions of macOS. PDF Expert is it’s made exclusively for Apple devices so it looks and works great on Mac, iPad and iPhones.
Let's look at the most fundamental transistor-switch circuit: an NPN switch. Instead, such a device would make more sense in situations of very high heat, such as for rocket engines. Transistor switches are critical circuit-building blocks they're used to make logic gates, which go on to create microcontrollers, microprocessors, and other integrated circuits. However, the main uses for a mechanical logic gate likely wouldn't be in consumer computing. 2.3 Transistors and Logic Gates The logic input A connected to the gate ports of both pMOS transistor (P1) and nMOS transistor (N1). Additionally, this set up is still slower than the speeds even a normal PC sees. Digital symbols: recall that we assign a range of analog voltages to each digital (logic) symbol assignment of voltage ranges depends on electrical properties of transistors being used typical values for '1': +5V, +3.3V, +2.9V, +1. The use of transistors for the construction of logic gates depends upon their utility as fast switches. The mechanical components start to break down after two billion cycles, limiting their usefulness. Logic Gates Use switch behavior of MOS transistors to implement logical functions: AND, OR, NOT. Such operating temperatures are encouraging. At 550 ☌ Lee's team managed to get the inverter to switch on and off 500,000 times a second - performing a computation with each cycle. Like a telegraph operator's Morse key, these levers physically make and break contact to pass or block currents.Īpplication of a voltage makes the levers move under electrostatic attraction. ![]() The device uses an arrangement of nanoscale levers instead of transistors. His team has developed a mechanical version of an inverter - the building block used to construct many types of logic gate, which themselves are a fundamental component of digital circuitry within computers. New Scientist reports on the effort to integrate mechanical computing into our modern electronic systems: Logic gates, made from transistors, control the flow of current in a circuit and can be used to create complex circuits that perform logical operations such. In order to get around this problem Te-Hao Lee and a team at Case Western Reserve University turned back to Babbage and his idea of mechanical computing. If you're planning to move within 5 - 7 years, an ARM may be a great option for you. Typically with an ARM you will qualify for a lower interest rate at the beginning of your loan. After that initial 7-year period, the interest rate on your home loan will begin to adjust on an annual basis (every 1 year) based on market rates. For example, with a 7/1 ARM home loan, the interest rate will remain fixed during the initial 7-year period on the life of the loan. Usually, after an initial fixed period, the interest rate on an ARM will adjust on an annual basis. Adjustable Rate MortgageĪn Adjustable Rate Mortgage (commonly referred to as an ARM), is a home loan that the interest payment changes, or adjusts, over the life of the loan. that may change over the life of your loan. *Note: For the sake of a basic definition we are excluding taxes, fees, etc. For example, if you have a 30-year fixed rate mortgage, the amount of your principal and interest payments will remain the same, every month for the entire 30 year period.* ![]() With a fixed rate mortgage the amount of your monthly payment will remain the same, year over year, for the entirety of your loan. Fixed Rate MortgageĪ Fixed Rate Mortgage is a home loan that will have the same interest rate for the entire payment period. There are multiple factors to consider, including your current and future financial picture and the length of time you plan to be in the home. When deciding on a loan, one of the first things you will need to assess is whether you would like a fixed rate or adjustable rate mortgage. Armed with this information, you are prepared to have a conversation with your mortgage banker about the best product to meet your financial goals. The actual products may vary depending on the market. ![]() In our experience, many borrowers are unaware of the number of loan products and don't know the different types of products and programs that might be available.īelow you’ll find information on the most common product distinctions. When it comes to selecting a mortgage for your new home purchase, there are a wide array of loan options available. ![]() The good news is razor designs have come a long way in recent years, and there are plenty of great options on the market that deliver smooth results without many of the irritating side effects. And if you choose to shave, then you’re likely familiar with razor bumps, burning, and irritation. Regardless of the method you chose, there are bound to be pros and cons. ![]() It will help reduce the redness and help the ingrown hair heal more quickly.It’s no secret that hair removal can be a frustrating, irritating (literally and figuratively), and costly experience. If, even with prevention (the good razor and exfoliation should help), you still get a bikini bump or two, treat them with a little acne cream that contains salicylic acid. Please leave a comment if you have, and let me know if/how well they work! There are creams and lotions out there, like Bikini Zone, that claim to prevent irritation after shaving or waxing your bikini line, but I’ve never tried them (can’t find them!). To avoid this, add a little baby powder as soon as your done and dried off, this prevent moisture and friction from irritating the skin. So you’ve finished, you’ve got a silky hair free bikini line, but if you’re like me, you’re thinking “how long until I have 15 little mosquito bites down there that look worse than the actual hair?” Bikini bumps are usually ingrown hairs and they happen more frequently down there because the skin is so thin and sensitive. If you’re just trying to avoid playing ‘peek-a-boo pubes’ with your bikini bottoms, slide them on to see how much you have left to shave periodically during this process. How much or little you shave is up to you. You’re not going against the grain, per se, but you’re going enough against it to whisk the hair away and leave the area smooth. Once again, if you’re extra sensitive, I would try this way first, but if no hair is coming off I find a side-to-side shave works best. This technique does avoid irritation, but it also seems to avoid actually removing any hair whatsoever. in the direction of hair growth) in order to avoid irritation. I’ve read a lot of guides that tell you to shave “with the grain” (i.e. Schick Intuition, Gilette Fusion ProGlide Power, Skintimate Shaving Cream You don’t have to try to find an extra-wide pair of unattractive bikini bottoms to avoid a beach humiliation, you don’t have to rub on sketchy chemicals that ‘magically’ disintegrate the hair, and you don’t have to show your hoo-ha to a total stranger (who will then proceed to drip hot wax on it and rip the hairs out herself!) Shaving your bikini area can be easy, pain free, and without irritation, so read on to find out how to do it: ![]() However, with bikini season in full throw, I felt like it was important that college girls know they have options when it comes to hair removal down there. Once you’ve picked out a good razor, cover the area with a generous layer of shaving cream or, failing that, hair conditioner (it’s just as creamy and nourishing if you’re out of shaving cream). I like the Schick Intuition because you can’t get much more lubrication than a big freaking bar of soap wrapped around the blades or try a men’s razor blade, because, whether they admit it or not, their facial skin is just a sensitive as ours is. I personally (cringe) use my regular razor that I use to shave my legs and underarms, but if you have sensitive skin, go to the drugstore and find a razor with lots of blades and some form of extra lubrication strip. Trim them down to ¼ of an inch or smaller (as small as you can get without cutting yourself) and then exfoliate the area with a gentle facial exfoliate. You don’t have to try to find an extra-wide pair of unattractive bikini bottoms to avoid a beach humiliation, you don’t have to rub on sketchy chemicals that ‘magically’ disintegrate the hair, and you don’t have to show your hoo-ha to a total stranger (who will then proceed to drip hot wax on it and rip the hairs out herself!) Shaving your bikini area can be easy, pain free, and without irritation, so read on to find out how to do it: 3 Simple Steps Step 1: Prepīefore you even touch a razor, you need to ask yourself an important and embarrassing question: how much do you have to lose? If your down-there hair is longer than a ¼ of an inch long, you need to take the scissors to those bad boys or shaving is going to be torture. ![]() I don’t really make it a habit of talking about pubic hair online. I, on the other hand, am a little more reserved. I’ve even heard of women going to get Brazilian waxes together. Some girls are really open about their private issues. |
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